They are the ones whose deeds have become worthless in this world and the Hereafter, and for them there will be no helpers.
The Saheeh International Quran Translation
أُو۟لَٰٓئِكَ ٱلَّذِينَ حَبِطَتْ أَعْمَٰلُهُمْ فِى ٱلدُّنْيَا وَٱلْءَاخِرَةِ وَمَا لَهُم مِّن نَّٰصِرِينَThey are the ones whose deeds have become worthless in this world and the Hereafter, and for them there will be no helpers.